Peptidomics and processing of regulatory peptides in the fruit fly Drosophila

More than a decade has passed since the release of the Drosophila melanogaster genome and the first predictions of fruit fly regulatory peptides (neuropeptides and peptide hormones). Since then, mass spectrometry-based methods have fuelled the chemical characterisation of regulatory peptides, from 7...

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Main Authors:	Dennis Pauls, Jiangtian Chen, Wencke Reiher, Jens T. Vanselow, Andreas Schlosser, Jörg Kahnt, Christian Wegener
Format:	Article
Language:	English
Published:	Elsevier 2014-06-01
Series:	EuPA Open Proteomics
Subjects:	Neuropeptides Peptide hormones LC–MS Direct mass spectrometric peptide profiling Quantitative mass spectrometry Proprotein processing
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212968514000117

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spelling	doaj-5fd19ab8146545a5a2bffaa33312716e2020-11-24T23:23:07ZengElsevierEuPA Open Proteomics2212-96852014-06-013C11412710.1016/j.euprot.2014.02.007Peptidomics and processing of regulatory peptides in the fruit fly DrosophilaDennis Pauls0Jiangtian Chen1Wencke Reiher2Jens T. Vanselow3Andreas Schlosser4Jörg Kahnt5Christian Wegener6Neurobiology and Genetics, Theodor-Boveri-Institute, Biocenter, University of Würzburg, Am Hubland, D-97074 Würzburg, GermanyNeurobiology and Genetics, Theodor-Boveri-Institute, Biocenter, University of Würzburg, Am Hubland, D-97074 Würzburg, GermanyNeurobiology and Genetics, Theodor-Boveri-Institute, Biocenter, University of Würzburg, Am Hubland, D-97074 Würzburg, GermanyRudolf Virchow Center for Experimental Biomedicine, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, GermanyRudolf Virchow Center for Experimental Biomedicine, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, GermanyMax-Planck-Institute of Terrestrial Microbiology, Karl-von-Frisch-Strasse 10, D-35043 Marburg, GermanyNeurobiology and Genetics, Theodor-Boveri-Institute, Biocenter, University of Würzburg, Am Hubland, D-97074 Würzburg, GermanyMore than a decade has passed since the release of the Drosophila melanogaster genome and the first predictions of fruit fly regulatory peptides (neuropeptides and peptide hormones). Since then, mass spectrometry-based methods have fuelled the chemical characterisation of regulatory peptides, from 7 Drosophila peptides in the pre-genomic area to more than 60 today. We review the development of fruit fly peptidomics, and present a comprehensive list of the regulatory peptides that have been chemically characterised until today. We also summarise the knowledge on peptide processing in Drosophila, which has strongly profited from a combination of MS-based techniques and the genetic tools available for the fruit fly. This combination has a very high potential to study the functional biology of peptide signalling on all levels, especially with the ongoing developments in quantitative MS in Drosophila.http://www.sciencedirect.com/science/article/pii/S2212968514000117NeuropeptidesPeptide hormonesLC–MSDirect mass spectrometric peptide profilingQuantitative mass spectrometryProprotein processing
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Dennis Pauls Jiangtian Chen Wencke Reiher Jens T. Vanselow Andreas Schlosser Jörg Kahnt Christian Wegener
spellingShingle	Dennis Pauls Jiangtian Chen Wencke Reiher Jens T. Vanselow Andreas Schlosser Jörg Kahnt Christian Wegener Peptidomics and processing of regulatory peptides in the fruit fly Drosophila EuPA Open Proteomics Neuropeptides Peptide hormones LC–MS Direct mass spectrometric peptide profiling Quantitative mass spectrometry Proprotein processing
author_facet	Dennis Pauls Jiangtian Chen Wencke Reiher Jens T. Vanselow Andreas Schlosser Jörg Kahnt Christian Wegener
author_sort	Dennis Pauls
title	Peptidomics and processing of regulatory peptides in the fruit fly Drosophila
title_short	Peptidomics and processing of regulatory peptides in the fruit fly Drosophila
title_full	Peptidomics and processing of regulatory peptides in the fruit fly Drosophila
title_fullStr	Peptidomics and processing of regulatory peptides in the fruit fly Drosophila
title_full_unstemmed	Peptidomics and processing of regulatory peptides in the fruit fly Drosophila
title_sort	peptidomics and processing of regulatory peptides in the fruit fly drosophila
publisher	Elsevier
series	EuPA Open Proteomics
issn	2212-9685
publishDate	2014-06-01
description	More than a decade has passed since the release of the Drosophila melanogaster genome and the first predictions of fruit fly regulatory peptides (neuropeptides and peptide hormones). Since then, mass spectrometry-based methods have fuelled the chemical characterisation of regulatory peptides, from 7 Drosophila peptides in the pre-genomic area to more than 60 today. We review the development of fruit fly peptidomics, and present a comprehensive list of the regulatory peptides that have been chemically characterised until today. We also summarise the knowledge on peptide processing in Drosophila, which has strongly profited from a combination of MS-based techniques and the genetic tools available for the fruit fly. This combination has a very high potential to study the functional biology of peptide signalling on all levels, especially with the ongoing developments in quantitative MS in Drosophila.
topic	Neuropeptides Peptide hormones LC–MS Direct mass spectrometric peptide profiling Quantitative mass spectrometry Proprotein processing
url	http://www.sciencedirect.com/science/article/pii/S2212968514000117
work_keys_str_mv	AT dennispauls peptidomicsandprocessingofregulatorypeptidesinthefruitflydrosophila AT jiangtianchen peptidomicsandprocessingofregulatorypeptidesinthefruitflydrosophila AT wenckereiher peptidomicsandprocessingofregulatorypeptidesinthefruitflydrosophila AT jenstvanselow peptidomicsandprocessingofregulatorypeptidesinthefruitflydrosophila AT andreasschlosser peptidomicsandprocessingofregulatorypeptidesinthefruitflydrosophila AT jorgkahnt peptidomicsandprocessingofregulatorypeptidesinthefruitflydrosophila AT christianwegener peptidomicsandprocessingofregulatorypeptidesinthefruitflydrosophila
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Peptidomics and processing of regulatory peptides in the fruit fly Drosophila

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