The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia
Tumour hypoxia reduces the efficacy of radiotherapy. Starting from a drug screen, here the authors demonstrate that the anti-malarial, atovaquone, reduces the oxygen consumption rate of cancer cells by inhibition of mitochondrial complex III and sensitises to radiotherapy by reducing tumour hypoxia.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2016-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12308 |
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doaj-5fcde319119841a9a1a9daedc3b995522021-05-11T11:05:51ZengNature Publishing GroupNature Communications2041-17232016-07-017111310.1038/ncomms12308The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxiaThomas M. Ashton0Emmanouil Fokas1Leoni A. Kunz-Schughart2Lisa K. Folkes3Selvakumar Anbalagan4Melanie Huether5Catherine J. Kelly6Giacomo Pirovano7Francesca M. Buffa8Ester M. Hammond9Michael Stratford10Ruth J. Muschel11Geoff S. Higgins12William Gillies McKenna13CRUK/MRC Oxford Institute for Radiation OncologyCRUK/MRC Oxford Institute for Radiation OncologyCRUK/MRC Oxford Institute for Radiation OncologyCRUK/MRC Oxford Institute for Radiation OncologyCRUK/MRC Oxford Institute for Radiation OncologyOncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden, and Helmholtz-Zentrum Dresden–Rossendorf, Institute of RadiooncologyCRUK/MRC Oxford Institute for Radiation OncologyCRUK/MRC Oxford Institute for Radiation OncologyCRUK/MRC Oxford Institute for Radiation OncologyCRUK/MRC Oxford Institute for Radiation OncologyCRUK/MRC Oxford Institute for Radiation OncologyCRUK/MRC Oxford Institute for Radiation OncologyCRUK/MRC Oxford Institute for Radiation OncologyCRUK/MRC Oxford Institute for Radiation OncologyTumour hypoxia reduces the efficacy of radiotherapy. Starting from a drug screen, here the authors demonstrate that the anti-malarial, atovaquone, reduces the oxygen consumption rate of cancer cells by inhibition of mitochondrial complex III and sensitises to radiotherapy by reducing tumour hypoxia.https://doi.org/10.1038/ncomms12308 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Thomas M. Ashton Emmanouil Fokas Leoni A. Kunz-Schughart Lisa K. Folkes Selvakumar Anbalagan Melanie Huether Catherine J. Kelly Giacomo Pirovano Francesca M. Buffa Ester M. Hammond Michael Stratford Ruth J. Muschel Geoff S. Higgins William Gillies McKenna |
| spellingShingle |
Thomas M. Ashton Emmanouil Fokas Leoni A. Kunz-Schughart Lisa K. Folkes Selvakumar Anbalagan Melanie Huether Catherine J. Kelly Giacomo Pirovano Francesca M. Buffa Ester M. Hammond Michael Stratford Ruth J. Muschel Geoff S. Higgins William Gillies McKenna The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia Nature Communications |
| author_facet |
Thomas M. Ashton Emmanouil Fokas Leoni A. Kunz-Schughart Lisa K. Folkes Selvakumar Anbalagan Melanie Huether Catherine J. Kelly Giacomo Pirovano Francesca M. Buffa Ester M. Hammond Michael Stratford Ruth J. Muschel Geoff S. Higgins William Gillies McKenna |
| author_sort |
Thomas M. Ashton |
| title |
The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia |
| title_short |
The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia |
| title_full |
The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia |
| title_fullStr |
The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia |
| title_full_unstemmed |
The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia |
| title_sort |
anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-07-01 |
| description |
Tumour hypoxia reduces the efficacy of radiotherapy. Starting from a drug screen, here the authors demonstrate that the anti-malarial, atovaquone, reduces the oxygen consumption rate of cancer cells by inhibition of mitochondrial complex III and sensitises to radiotherapy by reducing tumour hypoxia. |
| url |
https://doi.org/10.1038/ncomms12308 |
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