Characteristics of erythropoiesis regulation in population living at high altitude

• Main Authors: А В Makeshova, A A Levlna, Yu L Mamukova, A R Raimzhanov
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2004-11-01
• Series: Терапевтический архив
• Subjects: hemoglobin; serum iron; serum ferritin; transferrin receptors; erythropoietin; erythropoiesis; high altitude
• Online Access: https://ter-arkhiv.ru/0040-3660/article/view/29974
• ISSN: 0040-3660; 2309-5342

Aim. To study characteristics of iron deficiency anemia (IDA) in native population of high altitude territories. Material and methods. 1300 women living in Tien-Shan areas were examined for serum and erythrocytic ferritins (SF and EF), general iron-binding capacity of the serum, transferrin saturation with iron, transferrin, soluble transferrin receptor (TR), erythropoietin (EP), Hb, erythrocytes, erythrocytic indices. Results. Regulation of erythropoiesis in women living at high altitude is specific, i.e. disagreement between complete depletion of iron (by SF and EF) and normal level of Hb, erythrocytes, EP and TR. Conclusion. It is suggested that in population living at high altitudes (3000 m above the sea level and higher) long-term adaptation to hypoxia gave rise to an original mechanism of erythropoiesis regulation when all coming iron participates in hemoglobin synthesis without iron deposition. Under hypoxic hypoxia regulation of erythropoiesis is directed to prevention of tissue hypoxia.