PAX5 is part of a functional transcription factor network targeted in lymphoid leukemia.

PAX5 is part of a functional transcription factor network targeted in lymphoid leukemia.

One of the most frequently mutated proteins in human B-lineage leukemia is the transcription factor PAX5. These mutations often result in partial rather than complete loss of function of the transcription factor. While the functional dose of PAX5 has a clear connection to human malignancy, there is...

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Bibliographic Details
Main Authors: Kazuki Okuyama, Tobias Strid, Jacob Kuruvilla, Rajesh Somasundaram, Susana Cristobal, Emma Smith, Mahadesh Prasad, Thoas Fioretos, Henrik Lilljebjörn, Shamit Soneji, Stefan Lang, Jonas Ungerbäck, Mikael Sigvardsson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-08-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008280

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