FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2.

FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2.

The Fanconi anemia (FA)-BRCA pathway mediates repair of DNA interstrand crosslinks. The FA core complex, a multi-subunit ubiquitin ligase, participates in the detection of DNA lesions and monoubiquitinates two downstream FA proteins, FANCD2 and FANCI (or the ID complex). However, the regulation of t...

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Bibliographic Details
Main Authors: Maria Castella, Celine Jacquemont, Elizabeth L Thompson, Jung Eun Yeo, Ronald S Cheung, Jen-Wei Huang, Alexandra Sobeck, Eric A Hendrickson, Toshiyasu Taniguchi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-10-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4592014?pdf=render

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