nr3c1 null mutant zebrafish are viable and reveal DNA-binding-independent activities of the glucocorticoid receptor

nr3c1 null mutant zebrafish are viable and reveal DNA-binding-independent activities of the glucocorticoid receptor

Abstract Glucocorticoids (GCs) play important roles in developmental and physiological processes through the transcriptional activity of their cognate receptor (Gr). Using CRISPR/Cas9 technology, we established a zebrafish null Gr mutant line and compared its phenotypes with wild type and a zebrafis...

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Bibliographic Details
Main Authors: N. Facchinello, T. Skobo, G. Meneghetti, E. Colletti, A. Dinarello, N. Tiso, R. Costa, G. Gioacchini, O. Carnevali, F. Argenton, L. Colombo, L. Dalla Valle
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-04535-6

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