Maternal immune activation-induced PPARγ-dependent dysfunction of microglia associated with neurogenic impairment and aberrant postnatal behaviors in offspring

Maternal immune activation-induced PPARγ-dependent dysfunction of microglia associated with neurogenic impairment and aberrant postnatal behaviors in offspring

Maternal infection during pregnancy is an important factor involved in the pathogenesis of brain disorders in the offspring. Mounting evidence from maternal immune activation (MIA) animals indicates that microglial priming may contribute to neurodevelopmental abnormalities in the offspring. Because...

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Bibliographic Details
Main Authors: Qiuying Zhao, Qiaozhi Wang, Jiutai Wang, Minmin Tang, Shugui Huang, Ke Peng, Yue Han, Jinqiang Zhang, Guangyi Liu, Qi Fang, Zili You
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Neurobiology of Disease
Subjects:
Maternal immune activation
Offspring
Neurogenesis
Microglia activation
PPARγ
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118304911

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http://www.sciencedirect.com/science/article/pii/S0969996118304911

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