Ca<sup>2+</sup> Signalling Induced by NGF Identifies a Subset of Capsaicin-Excitable Neurons Displaying Enhanced Chemo-Nociception in Dorsal Root Ganglion Explants from Adult <i>pirt-GCaMP3</i> Mouse

Ca<sup>2+</sup> Signalling Induced by NGF Identifies a Subset of Capsaicin-Excitable Neurons Displaying Enhanced Chemo-Nociception in Dorsal Root Ganglion Explants from Adult <i>pirt-GCaMP3</i> Mouse

Nociceptors sense hazards via plasmalemmal cation channels, including transient receptor potential vanilloid 1 (TRPV1). Nerve growth factor (NGF) sensitises TRPV1 to capsaicin (CAPS), modulates nociceptor excitability and induces thermal hyperalgesia, but cellular mechanisms remain unclear. Confocal...

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Bibliographic Details
Main Authors: Gary W. Lawrence, Tomas H. Zurawski, J. Oliver Dolly
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
Ca<sup>2+</sup> imaging
nerve growth factor
TRPV1
capsaicin
nociception
Online Access:https://www.mdpi.com/1422-0067/22/5/2589

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