Integrin-β5, a miR-185-targeted gene, promotes hepatocellular carcinoma tumorigenesis by regulating β-catenin stability

Integrin-β5, a miR-185-targeted gene, promotes hepatocellular carcinoma tumorigenesis by regulating β-catenin stability

Abstract Background The tumour microenvironment is essential for cancer progress and metastasis. Integrin-β5 (ITGB5), a member of the integrin family, has been implicated to mediate the interactions of cells with the extracellular matrix (ECM) and promote tumorigenesis in several malignancies. Howev...

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Bibliographic Details
Main Authors: Zhikun Lin, Ruiping He, Haifeng Luo, Chang Lu, Zhen Ning, Yuanhang Wu, Chuanchun Han, Guang Tan, Zhongyu Wang
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Integrin-β5
β-catenin
miR-185
Hepatocellular carcinoma
Online Access:http://link.springer.com/article/10.1186/s13046-018-0691-9

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