Mechanistic insights into synergy between nalidixic acid and tetracycline against clinical isolates of Acinetobacter baumannii and Escherichia coli

Mechanistic insights into synergy between nalidixic acid and tetracycline against clinical isolates of Acinetobacter baumannii and Escherichia coli

Gaurav et al. report a synergistic interaction between nalidixic acid and tetracycline against multi-drug resistant bacteria Acinetobacter baumannii and Escherichia coli. They find that this synergy does not work for clinical isolates susceptible to antibiotics, suggesting the potential application...

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Main Authors: Amit Gaurav, Varsha Gupta, Sandeep K. Shrivastava, Ranjana Pathania
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02074-5
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spelling doaj-5fa4ed4a3c9c4db28bbbc07074870b2a2021-05-11T14:54:42ZengNature Publishing GroupCommunications Biology2399-36422021-05-014111210.1038/s42003-021-02074-5Mechanistic insights into synergy between nalidixic acid and tetracycline against clinical isolates of Acinetobacter baumannii and Escherichia coliAmit Gaurav0Varsha Gupta1Sandeep K. Shrivastava2Ranjana Pathania3Department of Biotechnology, Indian Institute of Technology RoorkeeDepartment of Microbiology, Government Medical College and Hospital ChandigarhCentre for Innovation, Research and Development, Dr. B. Lal Clinical Laboratory Pvt LtdDepartment of Biotechnology, Indian Institute of Technology RoorkeeGaurav et al. report a synergistic interaction between nalidixic acid and tetracycline against multi-drug resistant bacteria Acinetobacter baumannii and Escherichia coli. They find that this synergy does not work for clinical isolates susceptible to antibiotics, suggesting the potential application of nalidixic acid and tetracycline against the emergence of multi-drug resistant bacteria.https://doi.org/10.1038/s42003-021-02074-5
collection DOAJ
language English
format Article
sources DOAJ
author Amit Gaurav
Varsha Gupta
Sandeep K. Shrivastava
Ranjana Pathania
spellingShingle Amit Gaurav
Varsha Gupta
Sandeep K. Shrivastava
Ranjana Pathania
Mechanistic insights into synergy between nalidixic acid and tetracycline against clinical isolates of Acinetobacter baumannii and Escherichia coli
Communications Biology
author_facet Amit Gaurav
Varsha Gupta
Sandeep K. Shrivastava
Ranjana Pathania
author_sort Amit Gaurav
title Mechanistic insights into synergy between nalidixic acid and tetracycline against clinical isolates of Acinetobacter baumannii and Escherichia coli
title_short Mechanistic insights into synergy between nalidixic acid and tetracycline against clinical isolates of Acinetobacter baumannii and Escherichia coli
title_full Mechanistic insights into synergy between nalidixic acid and tetracycline against clinical isolates of Acinetobacter baumannii and Escherichia coli
title_fullStr Mechanistic insights into synergy between nalidixic acid and tetracycline against clinical isolates of Acinetobacter baumannii and Escherichia coli
title_full_unstemmed Mechanistic insights into synergy between nalidixic acid and tetracycline against clinical isolates of Acinetobacter baumannii and Escherichia coli
title_sort mechanistic insights into synergy between nalidixic acid and tetracycline against clinical isolates of acinetobacter baumannii and escherichia coli
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-05-01
description Gaurav et al. report a synergistic interaction between nalidixic acid and tetracycline against multi-drug resistant bacteria Acinetobacter baumannii and Escherichia coli. They find that this synergy does not work for clinical isolates susceptible to antibiotics, suggesting the potential application of nalidixic acid and tetracycline against the emergence of multi-drug resistant bacteria.
url https://doi.org/10.1038/s42003-021-02074-5
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AT varshagupta mechanisticinsightsintosynergybetweennalidixicacidandtetracyclineagainstclinicalisolatesofacinetobacterbaumanniiandescherichiacoli
AT sandeepkshrivastava mechanisticinsightsintosynergybetweennalidixicacidandtetracyclineagainstclinicalisolatesofacinetobacterbaumanniiandescherichiacoli
AT ranjanapathania mechanisticinsightsintosynergybetweennalidixicacidandtetracyclineagainstclinicalisolatesofacinetobacterbaumanniiandescherichiacoli
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