Permeability of Proteins at the Blood–Brain Barrier in the Normal Adult Mouse and Double Transgenic Mouse Model of Alzheimer's Disease

Permeability of Proteins at the Blood–Brain Barrier in the Normal Adult Mouse and Double Transgenic Mouse Model of Alzheimer's Disease

The permeability of albumin, insulin, and human Aβ 1–40 at the blood–brain barrier (BBB) was determined in the normal adult mouse (B6/SJL) and in the double transgenic Alzheimer mouse (APP, PS1) by using an I.V. bolus injection technique to quantify the permeability coefficient-surface area (PS) pro...

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Bibliographic Details
Main Authors: Joseph F. Poduslo, Geoffry L. Curran, Thomas M. Wengenack, Brian Malester, Karen Duff
Format: Article
Language:English
Published: Elsevier 2001-08-01
Series:Neurobiology of Disease
Subjects:
blood–brain barrier
protein permeability
albumin
insulin
Aβ
transgenic mice
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996101904024

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http://www.sciencedirect.com/science/article/pii/S0969996101904024

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