Two approaches to discovering and developing new drugs for Chagas disease

Two approaches to discovering and developing new drugs for Chagas disease

This review will focus on two general approaches carried out at the Sandler Center, University of California, San Francisco, to address the challenge of developing new drugs for the treatment of Chagas disease. The first approach is target-based drug discovery, and two specific targets, cytochrome P...

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Bibliographic Details
Main Authors: JH McKerrow, PS Doyle, JC Engel, LM Podust, SA Robertson, R Ferreira, T Saxton, M Arkin, ID Kerr, LS Brinen, CS Craik
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2009-07-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
Chagas
T. cruzi
drug
protease inhibitor
CYP51
HTS screen
amastigote
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900034

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