Improved detection of artifactual viral minority variants in high-throughput sequencing data

Improved detection of artifactual viral minority variants in high-throughput sequencing data

High-throughput sequencing (HTS) of viral samples provides important information on the presence of viral minority variants. However, detection and accurate quantification is limited by the capacity to distinguish biological from artificial variation. In this study, errors related to the Illumina Hi...

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Bibliographic Details
Main Authors: Matthijs Rudolf Albert Welkers, Marcel eJonges, Rienk eJeeninga, Marion P.G. Koopmans, Menno ede Jong
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Microbiology
Subjects:
Influenza Virus
high-throughput sequencing
error correction
minority variants
Illumina Hiseq2000
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00804/full

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