Estrogen regulates sex-specific localization of regulatory T cells in adipose tissue of obese female mice.
Regulatory T cells (Treg) play essential roles in maintaining immune homeostasis. Resident Treg in visceral adipose tissue (VAT-Treg) decrease in male obese mice, which leads to the development of obesity-associated chronic inflammations and insulin resistance. Although gender differences in immune...
Main Authors: | Akari Ishikawa, Tsutomu Wada, Sanshiro Nishimura, Tetsuo Ito, Akira Okekawa, Yasuhiro Onogi, Eri Watanabe, Azusa Sameshima, Tomoko Tanaka, Hiroshi Tsuneki, Shigeru Saito, Toshiyasu Sasaoka |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2020-01-01
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Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0230885 |
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