NPM1 deletion is associated with gross chromosomal rearrangements in leukemia.

NPM1 deletion is associated with gross chromosomal rearrangements in leukemia.

BACKGROUND: NPM1 gene at chromosome 5q35 is involved in recurrent translocations in leukemia and lymphoma. It also undergoes mutations in 60% of adult acute myeloid leukemia (AML) cases with normal karyotype. The incidence and significance of NPM1 deletion in human leukemia have not been elucidated....

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Main Authors: Roberta La Starza, Caterina Matteucci, Paolo Gorello, Lucia Brandimarte, Valentina Pierini, Barbara Crescenzi, Valeria Nofrini, Roberto Rosati, Enrico Gottardi, Giuseppe Saglio, Antonella Santucci, Laura Berchicci, Francesco Arcioni, Brunangelo Falini, Massimo Fabrizio Martelli, Constantina Sambani, Anna Aventin, Cristina Mecucci
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2943467?pdf=render

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