Paroxysmal nocturnal hemoglobinuria: a study of 17 cases.

• Main Author: Parab R
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 1990-01-01
• Series: Journal of Postgraduate Medicine
• Subjects: Adolescent; Adult; Female; Hemoglobinuria; Paroxysmal; blood; pathology; Human; Male; Middle Age; Retrospective Studies
• Online Access: http://www.jpgmonline.com/article.asp?issn=0022-3859;year=1990;volume=36;issue=1;spage=23;epage=6;aulast=Parab

Retrospective analysis of 17 cases of paroxysmal nocturnal hemoglobinuria (PNH) was carried out. The presenting feature of anaemia and hemoglobin of less than 9 gm% were observed in all cases. Fever, jaundice and bleeding tendency were observed in 8, 8 and 7 cases respectively. Bone marrow examination revealed megaloblastic features, erythroid hyperplasia and hypocellularity in 8, 7 and 2 cases respectively. Fourteen cases were refractory to the treatment, while only 3 showed response.