Development, validation and quantitative assessment of an enzymatic assay suitable for small molecule screening and profiling: A case-study

Development, validation and quantitative assessment of an enzymatic assay suitable for small molecule screening and profiling: A case-study

The successful discovery and subsequent development of small molecule inhibitors of drug targets relies on the establishment of robust, cost-effective, quantitative, and physiologically relevant in vitro assays that can support prolonged screening and optimization campaigns. The current study illust...

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Bibliographic Details
Main Authors: Vicente Sancenon, Wei Hau Goh, Aishwarya Sundaram, Kai Shih Er, Nidhi Johal, Svetlana Mukhina, Grant Carr, Saravanakumar Dhakshinamoorthy
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Biomolecular Detection and Quantification
Subjects:
Assay development
Small molecule
Screening
Phosphatase
Inhibitor
Mechanism-of-action
Online Access:http://www.sciencedirect.com/science/article/pii/S2214753515000236

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