Unique Presentation of Rosai-Dorfman Disease as Concomitant Appendiceal and Rectal Masses with IgG4-Positive Plasma Cells Diagnosed by Core Needle Biopsy

Unique Presentation of Rosai-Dorfman Disease as Concomitant Appendiceal and Rectal Masses with IgG4-Positive Plasma Cells Diagnosed by Core Needle Biopsy

Rosai-Dorfman disease (RDD), or sinus histiocytosis with massive lymphadenopathy, is a rare non-Langerhans cell histiocytosis. We report a case of a 69-year-old male with concurrent appendiceal and rectal masses who underwent CT-guided percutaneous biopsy. Histopathology confirmed a diagnosis of RDD...

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Main Authors: Jenna J. Poldemann, Benjamin H. Hinrichs, Abouelmagd Makramalla
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Case Reports in Oncological Medicine
Online Access:http://dx.doi.org/10.1155/2020/8814871
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spelling doaj-5f75b22500074124a1201f1950acf4eb2020-11-25T03:58:59ZengHindawi LimitedCase Reports in Oncological Medicine2090-67062090-67142020-01-01202010.1155/2020/88148718814871Unique Presentation of Rosai-Dorfman Disease as Concomitant Appendiceal and Rectal Masses with IgG4-Positive Plasma Cells Diagnosed by Core Needle BiopsyJenna J. Poldemann0Benjamin H. Hinrichs1Abouelmagd Makramalla2University of Cincinnati Medical Center, USAUniversity of Cincinnati Medical Center, USAUniversity of Cincinnati Medical Center, USARosai-Dorfman disease (RDD), or sinus histiocytosis with massive lymphadenopathy, is a rare non-Langerhans cell histiocytosis. We report a case of a 69-year-old male with concurrent appendiceal and rectal masses who underwent CT-guided percutaneous biopsy. Histopathology confirmed a diagnosis of RDD with IgG4-positive plasma cells. It is believed to be a subset of RDD that shares similar features with IgG4-related disease suggesting some overlap of the two diseases. Because gastrointestinal RDD accounts for less than 1% of extranodal disease, it is important to recognize this entity in order to guide management. We review the presentation, diagnosis, and treatment of gastrointestinal RDD and discuss the possible overlap with IgG4-related disease.http://dx.doi.org/10.1155/2020/8814871
collection DOAJ
language English
format Article
sources DOAJ
author Jenna J. Poldemann
Benjamin H. Hinrichs
Abouelmagd Makramalla
spellingShingle Jenna J. Poldemann
Benjamin H. Hinrichs
Abouelmagd Makramalla
Unique Presentation of Rosai-Dorfman Disease as Concomitant Appendiceal and Rectal Masses with IgG4-Positive Plasma Cells Diagnosed by Core Needle Biopsy
Case Reports in Oncological Medicine
author_facet Jenna J. Poldemann
Benjamin H. Hinrichs
Abouelmagd Makramalla
author_sort Jenna J. Poldemann
title Unique Presentation of Rosai-Dorfman Disease as Concomitant Appendiceal and Rectal Masses with IgG4-Positive Plasma Cells Diagnosed by Core Needle Biopsy
title_short Unique Presentation of Rosai-Dorfman Disease as Concomitant Appendiceal and Rectal Masses with IgG4-Positive Plasma Cells Diagnosed by Core Needle Biopsy
title_full Unique Presentation of Rosai-Dorfman Disease as Concomitant Appendiceal and Rectal Masses with IgG4-Positive Plasma Cells Diagnosed by Core Needle Biopsy
title_fullStr Unique Presentation of Rosai-Dorfman Disease as Concomitant Appendiceal and Rectal Masses with IgG4-Positive Plasma Cells Diagnosed by Core Needle Biopsy
title_full_unstemmed Unique Presentation of Rosai-Dorfman Disease as Concomitant Appendiceal and Rectal Masses with IgG4-Positive Plasma Cells Diagnosed by Core Needle Biopsy
title_sort unique presentation of rosai-dorfman disease as concomitant appendiceal and rectal masses with igg4-positive plasma cells diagnosed by core needle biopsy
publisher Hindawi Limited
series Case Reports in Oncological Medicine
issn 2090-6706
2090-6714
publishDate 2020-01-01
description Rosai-Dorfman disease (RDD), or sinus histiocytosis with massive lymphadenopathy, is a rare non-Langerhans cell histiocytosis. We report a case of a 69-year-old male with concurrent appendiceal and rectal masses who underwent CT-guided percutaneous biopsy. Histopathology confirmed a diagnosis of RDD with IgG4-positive plasma cells. It is believed to be a subset of RDD that shares similar features with IgG4-related disease suggesting some overlap of the two diseases. Because gastrointestinal RDD accounts for less than 1% of extranodal disease, it is important to recognize this entity in order to guide management. We review the presentation, diagnosis, and treatment of gastrointestinal RDD and discuss the possible overlap with IgG4-related disease.
url http://dx.doi.org/10.1155/2020/8814871
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AT benjaminhhinrichs uniquepresentationofrosaidorfmandiseaseasconcomitantappendicealandrectalmasseswithigg4positiveplasmacellsdiagnosedbycoreneedlebiopsy
AT abouelmagdmakramalla uniquepresentationofrosaidorfmandiseaseasconcomitantappendicealandrectalmasseswithigg4positiveplasmacellsdiagnosedbycoreneedlebiopsy
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