Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease

Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant Parkinson's disease (PD). LRRK2 contains functional GTPase and kinase domains. The most common G2019S mutation enhances the kinase activity of LRRK2 in vitro whereas G2019S LRRK2 expression in cultur...

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Bibliographic Details
Main Authors: Elpida Tsika, An Phu Tran Nguyen, Julien Dusonchet, Philippe Colin, Bernard L. Schneider, Darren J. Moore
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Neurobiology of Disease
Subjects:
LRRK2
Kinase
Parkinsonism
Parkinson's disease
Adenovirus
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115000534

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