Infrapatellar fat pad-derived mesenchymal stem cell-based spheroids enhance their therapeutic efficacy to reverse synovitis and fat pad fibrosis

Infrapatellar fat pad-derived mesenchymal stem cell-based spheroids enhance their therapeutic efficacy to reverse synovitis and fat pad fibrosis

Abstract Background To investigate the in vitro and in vivo anti-inflammatory/anti-fibrotic capacity of IFP-MSC manufactured as 3D spheroids. Our hypothesis is that IFP-MSC do not require prior cell priming to acquire a robust immunomodulatory phenotype in vitro in order to efficiently reverse synov...

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Bibliographic Details
Main Authors: Dimitrios Kouroupis, Melissa A. Willman, Thomas M. Best, Lee D. Kaplan, Diego Correa
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells (MSC)
Infrapatellar fat pad (IFP)
CD146 subpopulations
Cell priming
Spheroid cultures
Synovitis
Online Access:https://doi.org/10.1186/s13287-020-02107-6

Internet

https://doi.org/10.1186/s13287-020-02107-6

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