Drug discovery of anticancer drugs targeting methylenetetrahydrofolate dehydrogenase 2

Drug discovery of anticancer drugs targeting methylenetetrahydrofolate dehydrogenase 2

Many anticancer drugs have serious adverse effects; therefore, it is necessary to target features specific to cancer cells to minimize the effects on healthy cells. Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) was reported to be specifically enhanced in cancer. We confirmed the validity of MTH...

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Bibliographic Details
Main Authors: Ayumu Asai, Jun Koseki, Masamitsu Konno, Tatsunori Nishimura, Noriko Gotoh, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Heliyon
Subjects:
Cancer research
Pharmaceutical science
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844018341550

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