Paeoniflorin Ameliorates Macrophage Infiltration and Activation by Inhibiting the TLR4 Signaling Pathway in Diabetic Nephropathy

Paeoniflorin Ameliorates Macrophage Infiltration and Activation by Inhibiting the TLR4 Signaling Pathway in Diabetic Nephropathy

Paeoniflorin (PF) is the primary component of total glucosides of paeony (TGP). It exerts multiple effects, including immunoregulatory and anti-inflammatory effects. Our previous study has found that PF has a remarkable renal-protective effect in diabetic mice, but exact mechanism has not been clari...

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Bibliographic Details
Main Authors: Yun-xia Shao, Qian Gong, Xiang-Ming Qi, Kun Wang, Yong-gui Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Pharmacology
Subjects:
paeoniflorin
toll-like receptor 4
macrophages
diabetic nephropathy
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00566/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00566/full

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