Pharmacological correctors of mutant CFTR mistrafficking
The lack of phenylalanine 508 (∆F508 mutation) in the CFTR Cl- channel represents the most frequent cause of cystic fibrosis (CF), a genetic disease affecting multiple organs such lung, pancreas, and liver. ∆F508 causes instability and misfolding of CFTR protein leading to early degradation in the...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2012-10-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00175/full |