The role of cancer-associated fibroblasts in renal cell carcinoma. An example of tumor modulation through tumor/non-tumor cell interactions

Cancer-associated fibroblasts (CAF) are a cellular compartment of the tumor microenvironment (TME) with critical roles in tumor development. Fibroblast activation protein-α (FAP) is one of the proteins expressed by CAF and its immunohistochemical detection in routine practice is associated with tumo...

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Main Authors: Peio Errarte, Gorka Larrinaga, José I. López
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Journal of Advanced Research
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123219301560
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spelling doaj-5f55b4ddea8a4f32aa1aa5444df992ed2020-11-25T01:08:21ZengElsevierJournal of Advanced Research2090-12322020-01-0121103108The role of cancer-associated fibroblasts in renal cell carcinoma. An example of tumor modulation through tumor/non-tumor cell interactionsPeio Errarte0Gorka Larrinaga1José I. López2Department of Physiology, University of The Basque Country (UPV/EHU), 48940 Leioa, Spain; Biomarkers in Cancer Unit, Biocruces-Bizkaia Health Research Institute, 48903 Barakaldo, SpainDepartment of Physiology, University of The Basque Country (UPV/EHU), 48940 Leioa, Spain; Biomarkers in Cancer Unit, Biocruces-Bizkaia Health Research Institute, 48903 Barakaldo, Spain; Department of Nursing I, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainBiomarkers in Cancer Unit, Biocruces-Bizkaia Health Research Institute, 48903 Barakaldo, Spain; Department of Pathology, Cruces University Hospital, 48903 Barakaldo, Spain; Department of Medical-Surgical Specialties, University of the Basque Country, 48940 Leioa, Spain; Corresponding author at: Biomarkers in Cancer Unit, Biocruces-Bizkaia Health Research Institute, 48903 Barakaldo, Spain.Cancer-associated fibroblasts (CAF) are a cellular compartment of the tumor microenvironment (TME) with critical roles in tumor development. Fibroblast activation protein-α (FAP) is one of the proteins expressed by CAF and its immunohistochemical detection in routine practice is associated with tumor aggressiveness and shorter patient survival. For these reasons, FAP seems a good prognostic marker in many malignant neoplasms, including renal cell carcinoma (RCC). The start point of this Perspective paper is to review the role of CAF in the modulation of renal cell carcinoma evolution. In this sense, CAF have demonstrated to develop important protumor and/or antitumor activities. This apparent paradox suggests that some type of temporally or spatially-related specialization is present in this cellular compartment during tumor evolution. The end point is to remark that tumor/non-tumor cell interactions, in particular the symbiotic tumor/CAF connections, are permanent and ever-changing crucial phenomena along tumor lifetime. Interestingly, these interactions may be responsible of many therapeutic failures. Keywords: Renal cell carcinoma, Cancer associated fibroblast, Fibroblast activation protein, Prognosis, Targeted therapyhttp://www.sciencedirect.com/science/article/pii/S2090123219301560
collection DOAJ
language English
format Article
sources DOAJ
author Peio Errarte
Gorka Larrinaga
José I. López
spellingShingle Peio Errarte
Gorka Larrinaga
José I. López
The role of cancer-associated fibroblasts in renal cell carcinoma. An example of tumor modulation through tumor/non-tumor cell interactions
Journal of Advanced Research
author_facet Peio Errarte
Gorka Larrinaga
José I. López
author_sort Peio Errarte
title The role of cancer-associated fibroblasts in renal cell carcinoma. An example of tumor modulation through tumor/non-tumor cell interactions
title_short The role of cancer-associated fibroblasts in renal cell carcinoma. An example of tumor modulation through tumor/non-tumor cell interactions
title_full The role of cancer-associated fibroblasts in renal cell carcinoma. An example of tumor modulation through tumor/non-tumor cell interactions
title_fullStr The role of cancer-associated fibroblasts in renal cell carcinoma. An example of tumor modulation through tumor/non-tumor cell interactions
title_full_unstemmed The role of cancer-associated fibroblasts in renal cell carcinoma. An example of tumor modulation through tumor/non-tumor cell interactions
title_sort role of cancer-associated fibroblasts in renal cell carcinoma. an example of tumor modulation through tumor/non-tumor cell interactions
publisher Elsevier
series Journal of Advanced Research
issn 2090-1232
publishDate 2020-01-01
description Cancer-associated fibroblasts (CAF) are a cellular compartment of the tumor microenvironment (TME) with critical roles in tumor development. Fibroblast activation protein-α (FAP) is one of the proteins expressed by CAF and its immunohistochemical detection in routine practice is associated with tumor aggressiveness and shorter patient survival. For these reasons, FAP seems a good prognostic marker in many malignant neoplasms, including renal cell carcinoma (RCC). The start point of this Perspective paper is to review the role of CAF in the modulation of renal cell carcinoma evolution. In this sense, CAF have demonstrated to develop important protumor and/or antitumor activities. This apparent paradox suggests that some type of temporally or spatially-related specialization is present in this cellular compartment during tumor evolution. The end point is to remark that tumor/non-tumor cell interactions, in particular the symbiotic tumor/CAF connections, are permanent and ever-changing crucial phenomena along tumor lifetime. Interestingly, these interactions may be responsible of many therapeutic failures. Keywords: Renal cell carcinoma, Cancer associated fibroblast, Fibroblast activation protein, Prognosis, Targeted therapy
url http://www.sciencedirect.com/science/article/pii/S2090123219301560
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