Decoupling the Effects of the Amyloid Precursor Protein From Amyloid-β Plaques on Axonal Transport Dynamics in the Living Brain

Decoupling the Effects of the Amyloid Precursor Protein From Amyloid-β Plaques on Axonal Transport Dynamics in the Living Brain

Amyloid precursor protein (APP) is the precursor to Aβ plaques. The cytoplasmic domain of APP mediates attachment of vesicles to molecular motors for axonal transport. In APP-KO mice, transport of Mn2+ is decreased. In old transgenic mice expressing mutated human (APPSwInd) linked to Familial Alzhei...

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Bibliographic Details
Main Authors: Christopher S. Medina, Taylor W. Uselman, Daniel R. Barto, Frances Cháves, Russell E. Jacobs, Elaine L. Bearer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
transgenic mice for Alzheimer’s disease investigation
amyloid precursor protein (APP)
fast microtubule-based axonal transport
CA3 of the hippocampus
dentate gyrus and septal nuclei
manganese-enhanced magnetic resonance imaging (MEMRI)
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00501/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00501/full

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