Total Synthesis of Novel Skeleton Flavan-Alkaloids
The first total synthesis of novel skeleton natural compounds kinkeloids A and B, a group of newly discovered flavan alkaloids isolated from the African plant <i>Combretum micranthum</i>, are described in this study. The key and final step are achieved by Mannich reaction, through which...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/19/4491 |
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doaj-5f31fe2af6e44bb7b90167c7572a1ab42020-11-25T04:00:32ZengMDPI AGMolecules1420-30492020-09-01254491449110.3390/molecules25194491Total Synthesis of Novel Skeleton Flavan-AlkaloidsJing Zhen0James E. Simon1Qingli Wu2Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers University, 160 Frelinghuysen Road, Piscataway, NJ 08854, USADepartment of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers University, 160 Frelinghuysen Road, Piscataway, NJ 08854, USADepartment of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers University, 160 Frelinghuysen Road, Piscataway, NJ 08854, USAThe first total synthesis of novel skeleton natural compounds kinkeloids A and B, a group of newly discovered flavan alkaloids isolated from the African plant <i>Combretum micranthum</i>, are described in this study. The key and final step are achieved by Mannich reaction, through which the piperidine moiety couples to the flavan moiety. The identities of synthesized kinkeloids were further confirmed through a comparison with the ones in the plant leaves extract using LC/MS.https://www.mdpi.com/1420-3049/25/19/4491<i>Combretum micranthum</i>kinkeloids Akinkeloids B |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jing Zhen James E. Simon Qingli Wu |
| spellingShingle |
Jing Zhen James E. Simon Qingli Wu Total Synthesis of Novel Skeleton Flavan-Alkaloids Molecules <i>Combretum micranthum</i> kinkeloids A kinkeloids B |
| author_facet |
Jing Zhen James E. Simon Qingli Wu |
| author_sort |
Jing Zhen |
| title |
Total Synthesis of Novel Skeleton Flavan-Alkaloids |
| title_short |
Total Synthesis of Novel Skeleton Flavan-Alkaloids |
| title_full |
Total Synthesis of Novel Skeleton Flavan-Alkaloids |
| title_fullStr |
Total Synthesis of Novel Skeleton Flavan-Alkaloids |
| title_full_unstemmed |
Total Synthesis of Novel Skeleton Flavan-Alkaloids |
| title_sort |
total synthesis of novel skeleton flavan-alkaloids |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2020-09-01 |
| description |
The first total synthesis of novel skeleton natural compounds kinkeloids A and B, a group of newly discovered flavan alkaloids isolated from the African plant <i>Combretum micranthum</i>, are described in this study. The key and final step are achieved by Mannich reaction, through which the piperidine moiety couples to the flavan moiety. The identities of synthesized kinkeloids were further confirmed through a comparison with the ones in the plant leaves extract using LC/MS. |
| topic |
<i>Combretum micranthum</i> kinkeloids A kinkeloids B |
| url |
https://www.mdpi.com/1420-3049/25/19/4491 |
| work_keys_str_mv |
AT jingzhen totalsynthesisofnovelskeletonflavanalkaloids AT jamesesimon totalsynthesisofnovelskeletonflavanalkaloids AT qingliwu totalsynthesisofnovelskeletonflavanalkaloids |
| _version_ |
1724450005903736832 |