Baclofen for maintenance treatment of opioid dependence: A randomized double-blind placebo-controlled clinical trial [ISRCTN32121581]

• Main Authors: Ahmadi-Abhari Seyed Ali, Radgoodarzi Reza, Assadi Seyed Mohammad
• Format: Article
• Language: English
• Published: BMC 2003-11-01
• Series: BMC Psychiatry
• Online Access: http://www.biomedcentral.com/1471-244X/3/16

<p>Abstract</p> <p>Background</p> <p>Results of preclinical studies suggest that the GABA_Breceptor agonist baclofen may be useful in treatment of opioid dependence. This study was aimed at assessing the possible efficacy of baclofen for maintenance treatment of opioid dependence.</p> <p>Methods</p> <p>A total of 40 opioid-dependent patients were detoxified and randomly assigned to receive baclofen (60 mg/day) or placebo in a 12-week, double blind, parallel-group trial. Primary outcome measure was retention in treatment. Secondary outcome measures included opioids and alcohol use according to urinalysis and self-report ratings, intensity of opioid craving assessed with a visual analogue scale, opioid withdrawal symptoms as measured by the Short Opiate Withdrawal Scale and depression scores on the Hamilton inventory.</p> <p>Results</p> <p>Treatment retention was significantly higher in the baclofen group. Baclofen also showed a significant superiority over placebo in terms of opiate withdrawal syndrome and depressive symptoms. Non-significant, but generally favorable responses were seen in the baclofen group with other outcome measures including intensity of opioid craving and self-reported opioid and alcohol use. However, no significant difference was seen in the rates of opioid-positive urine tests. Additionally, the drug side effects of the two groups were not significantly different.</p> <p>Conclusion</p> <p>The results support further study of baclofen in the maintenance treatment of opioid dependence.</p>