Antiangiogenesis, Loss of Cell Adhesion and Apoptosis Are Involved in the Antitumoral Activity of Proteases from V. cundinamarcensis (C. candamarcensis) in Murine Melanoma B16F1

Antiangiogenesis, Loss of Cell Adhesion and Apoptosis Are Involved in the Antitumoral Activity of Proteases from V. cundinamarcensis (C. candamarcensis) in Murine Melanoma B16F1

The proteolytic enzymes from V. cundinamarcensis latex, (P1G10), display healing activity in animal models following various types of lesions. P1G10 or the purified isoforms act as mitogens on fibroblast and epithelial cells by stimulating angiogenesis and wound healing in gastric and cutaneous ulce...

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Bibliographic Details
Main Authors: Dalton Dittz, Cinthia Figueiredo, Fernanda O. Lemos, Celso T. R. Viana, Silvia P. Andrade, Elaine M. Souza-Fagundes, Ricardo T. Fujiwara, Carlos E. Salas, Miriam T. P. Lopes
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:International Journal of Molecular Sciences
Subjects:
proteases
V. cundinamarcensis
antitumoral
melanoma B16F1
apoptosis
anchorage loss
Online Access:http://www.mdpi.com/1422-0067/16/4/7027

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