Melatonin—A Potent Therapeutic for Stroke and Stroke-Related Dementia

Secreted by the pineal gland to regulate the circadian rhythm, melatonin is a powerful antioxidant that has been used to combat oxidative stress in the central nervous system. Melatonin-based therapies have been shown to provide neuroprotective effects in the setting of ischemic stroke by mitigating...

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Main Authors:	Nadia Sadanandan, Blaise Cozene, Justin Cho, You Jeong Park, Madeline Saft, Bella Gonzales-Portillo, Cesar V. Borlongan
Format:	Article
Language:	English
Published:	MDPI AG 2020-07-01
Series:	Antioxidants
Subjects:	antioxidant melatonin cerebral ischemia oxidative stress stem cells
Online Access:	https://www.mdpi.com/2076-3921/9/8/672

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spelling	doaj-5f1bd04f372d4e48852be17273aea2ce2020-11-25T02:56:32ZengMDPI AGAntioxidants2076-39212020-07-01967267210.3390/antiox9080672Melatonin—A Potent Therapeutic for Stroke and Stroke-Related DementiaNadia Sadanandan0Blaise Cozene1Justin Cho2You Jeong Park3Madeline Saft4Bella Gonzales-Portillo5Cesar V. Borlongan6Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USADepartment of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USADepartment of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USADepartment of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USADepartment of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USADepartment of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USADepartment of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USASecreted by the pineal gland to regulate the circadian rhythm, melatonin is a powerful antioxidant that has been used to combat oxidative stress in the central nervous system. Melatonin-based therapies have been shown to provide neuroprotective effects in the setting of ischemic stroke by mitigating neuroinflammation and accelerating brain tissue restoration. Melatonin treatment includes injection of exogenous melatonin, pineal gland grafting and melatonin-mediated stem cell therapy. This review will discuss the current preclinical and clinical studies investigating melatonin-based therapeutics to treat stroke.https://www.mdpi.com/2076-3921/9/8/672antioxidantmelatonincerebral ischemiaoxidative stressstem cells
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Nadia Sadanandan Blaise Cozene Justin Cho You Jeong Park Madeline Saft Bella Gonzales-Portillo Cesar V. Borlongan
spellingShingle	Nadia Sadanandan Blaise Cozene Justin Cho You Jeong Park Madeline Saft Bella Gonzales-Portillo Cesar V. Borlongan Melatonin—A Potent Therapeutic for Stroke and Stroke-Related Dementia Antioxidants antioxidant melatonin cerebral ischemia oxidative stress stem cells
author_facet	Nadia Sadanandan Blaise Cozene Justin Cho You Jeong Park Madeline Saft Bella Gonzales-Portillo Cesar V. Borlongan
author_sort	Nadia Sadanandan
title	Melatonin—A Potent Therapeutic for Stroke and Stroke-Related Dementia
title_short	Melatonin—A Potent Therapeutic for Stroke and Stroke-Related Dementia
title_full	Melatonin—A Potent Therapeutic for Stroke and Stroke-Related Dementia
title_fullStr	Melatonin—A Potent Therapeutic for Stroke and Stroke-Related Dementia
title_full_unstemmed	Melatonin—A Potent Therapeutic for Stroke and Stroke-Related Dementia
title_sort	melatonin—a potent therapeutic for stroke and stroke-related dementia
publisher	MDPI AG
series	Antioxidants
issn	2076-3921
publishDate	2020-07-01
description	Secreted by the pineal gland to regulate the circadian rhythm, melatonin is a powerful antioxidant that has been used to combat oxidative stress in the central nervous system. Melatonin-based therapies have been shown to provide neuroprotective effects in the setting of ischemic stroke by mitigating neuroinflammation and accelerating brain tissue restoration. Melatonin treatment includes injection of exogenous melatonin, pineal gland grafting and melatonin-mediated stem cell therapy. This review will discuss the current preclinical and clinical studies investigating melatonin-based therapeutics to treat stroke.
topic	antioxidant melatonin cerebral ischemia oxidative stress stem cells
url	https://www.mdpi.com/2076-3921/9/8/672
work_keys_str_mv	AT nadiasadanandan melatoninapotenttherapeuticforstrokeandstrokerelateddementia AT blaisecozene melatoninapotenttherapeuticforstrokeandstrokerelateddementia AT justincho melatoninapotenttherapeuticforstrokeandstrokerelateddementia AT youjeongpark melatoninapotenttherapeuticforstrokeandstrokerelateddementia AT madelinesaft melatoninapotenttherapeuticforstrokeandstrokerelateddementia AT bellagonzalesportillo melatoninapotenttherapeuticforstrokeandstrokerelateddementia AT cesarvborlongan melatoninapotenttherapeuticforstrokeandstrokerelateddementia
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Melatonin—A Potent Therapeutic for Stroke and Stroke-Related Dementia

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