Molecular determinants for the strictly compartmentalized expression of kainate receptors in CA3 pyramidal cells

Molecular determinants for the strictly compartmentalized expression of kainate receptors in CA3 pyramidal cells

Kainate receptors are selectively found at CA3-mossy fibre synapses, although the mechanisms regulating this compartmentalisation have yet to be determined. Here, the authors find KAR segregation is dependent on the amount of GluK2a protein and an interaction between the GluK2 C-terminal domain and...

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Main Authors: Sabine Fièvre, Mario Carta, Ingrid Chamma, Virginie Labrousse, Olivier Thoumine, Christophe Mulle
Format: Article
Language:English
Published: Nature Publishing Group 2016-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12738
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spelling doaj-5f17c5df5f1f4d16b53ec3e6fb6247892021-05-11T11:12:46ZengNature Publishing GroupNature Communications2041-17232016-09-017111210.1038/ncomms12738Molecular determinants for the strictly compartmentalized expression of kainate receptors in CA3 pyramidal cellsSabine Fièvre0Mario Carta1Ingrid Chamma2Virginie Labrousse3Olivier Thoumine4Christophe Mulle5Interdisciplinary Institute for Neuroscience, CNRS UMR 5297, University of BordeauxInterdisciplinary Institute for Neuroscience, CNRS UMR 5297, University of BordeauxInterdisciplinary Institute for Neuroscience, CNRS UMR 5297, University of BordeauxInterdisciplinary Institute for Neuroscience, CNRS UMR 5297, University of BordeauxInterdisciplinary Institute for Neuroscience, CNRS UMR 5297, University of BordeauxInterdisciplinary Institute for Neuroscience, CNRS UMR 5297, University of BordeauxKainate receptors are selectively found at CA3-mossy fibre synapses, although the mechanisms regulating this compartmentalisation have yet to be determined. Here, the authors find KAR segregation is dependent on the amount of GluK2a protein and an interaction between the GluK2 C-terminal domain and N-cadherin.https://doi.org/10.1038/ncomms12738
collection DOAJ
language English
format Article
sources DOAJ
author Sabine Fièvre
Mario Carta
Ingrid Chamma
Virginie Labrousse
Olivier Thoumine
Christophe Mulle
spellingShingle Sabine Fièvre
Mario Carta
Ingrid Chamma
Virginie Labrousse
Olivier Thoumine
Christophe Mulle
Molecular determinants for the strictly compartmentalized expression of kainate receptors in CA3 pyramidal cells
Nature Communications
author_facet Sabine Fièvre
Mario Carta
Ingrid Chamma
Virginie Labrousse
Olivier Thoumine
Christophe Mulle
author_sort Sabine Fièvre
title Molecular determinants for the strictly compartmentalized expression of kainate receptors in CA3 pyramidal cells
title_short Molecular determinants for the strictly compartmentalized expression of kainate receptors in CA3 pyramidal cells
title_full Molecular determinants for the strictly compartmentalized expression of kainate receptors in CA3 pyramidal cells
title_fullStr Molecular determinants for the strictly compartmentalized expression of kainate receptors in CA3 pyramidal cells
title_full_unstemmed Molecular determinants for the strictly compartmentalized expression of kainate receptors in CA3 pyramidal cells
title_sort molecular determinants for the strictly compartmentalized expression of kainate receptors in ca3 pyramidal cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-09-01
description Kainate receptors are selectively found at CA3-mossy fibre synapses, although the mechanisms regulating this compartmentalisation have yet to be determined. Here, the authors find KAR segregation is dependent on the amount of GluK2a protein and an interaction between the GluK2 C-terminal domain and N-cadherin.
url https://doi.org/10.1038/ncomms12738
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