The putative signal peptide of glucagon-like peptide-1 receptor is not required for receptor synthesis but promotes receptor expression

The putative signal peptide of glucagon-like peptide-1 receptor is not required for receptor synthesis but promotes receptor expression

GLP-1R (glucagon-like peptide-1 receptor) mediates the ‘incretin effect’ and many other anti-diabetic actions of its cognate ligand, GLP-1 (glucagon-like peptide-1). It belongs to the class B family of GPCRs (G protein-coupled receptors) and possesses an N-terminal putative SP (signal peptide). It...

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Bibliographic Details
Main Authors: Yunjun Ge, Dehua Yang, Antao Dai, Caihong Zhou, Yue Zhu, Ming‑Wei Wang
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2014-11-01
Series:Bioscience Reports
Subjects:
epitope tag
G protein-coupled receptor
glucagon-like peptide-1 receptor
glycosylation
signal peptide
synthesis
Online Access:http://www.bioscirep.org/bsr/034/e152/bsr034e152.htm

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