| Summary: | <p>Abstract</p> <p>The chromosomal translocation (11;14)(q13;q32) rearranging the locus for cyclin D1 (<it>CCND1</it>) to that of the immunoglobulin heavy chain (<it>IGH</it>) can be found in virtually all cases of mantle cell lymphoma (MCL), while other <it>CCND1 </it>translocations are extremely rare. As <it>CCND1 </it>overexpression and activation is a hallmark of MCL it is regarded as a central biological mechanism in the development and maintenance of this disease.</p> <p>Here we present a patient initially diagnosed with chronic lymphocytic leukemia (CLL) where chromosome banding analysis revealed, among other aberrations, a translocation (11;22)(q13;q11.2). We show by fluorescence in situ hybridization (FISH) analysis that on chromosome 22 the immunoglobulin light chain lambda (<it>IGL</it>) is involved in this cytogenetic aberration. Additionally, we demonstrate the resulting overexpression of <it>CCND1 </it>on the RNA and protein level, thereby consolidating the new diagnosis of a MCL-like B-cell neoplasia. Summing up, we described a rare case of t(11;22)(q13;q11.2) in a MCL-like neoplasia and showed that this aberration leads to an overexpression of <it>CCND1 </it>which is regarded as a key biological feature in MCL. This case underlines the importance of cytogenetic analyses especially in atypical cases of B cell lymphomas.</p>
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