Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy

The immunosuppressive tumor environment and the lack of functional anti-tumor immunity are major limiting factors in immunotherapy. Here the authors show that human and mouse tumors are infiltrated by virus-specific memory T cells, which can be harnessed by viral peptides to induce local and systemi...

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Main Authors:	Pamela C. Rosato, Sathi Wijeyesinghe, J. Michael Stolley, Christine E. Nelson, Rachel L. Davis, Luke S. Manlove, Christopher A. Pennell, Bruce R. Blazar, Clark C. Chen, Melissa A. Geller, Vaiva Vezys, David Masopust
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-08534-1

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spelling	doaj-5f068cea4ece4349a43cb5cd50da36002021-05-11T12:24:04ZengNature Publishing GroupNature Communications2041-17232019-02-011011910.1038/s41467-019-08534-1Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapyPamela C. Rosato0Sathi Wijeyesinghe1J. Michael Stolley2Christine E. Nelson3Rachel L. Davis4Luke S. Manlove5Christopher A. Pennell6Bruce R. Blazar7Clark C. Chen8Melissa A. Geller9Vaiva Vezys10David Masopust11Department of Microbiology and Immunology, Center for Immunology, University of MinnesotaDepartment of Microbiology and Immunology, Center for Immunology, University of MinnesotaDepartment of Microbiology and Immunology, Center for Immunology, University of MinnesotaDepartment of Microbiology and Immunology, Center for Immunology, University of MinnesotaDepartment of Microbiology and Immunology, Center for Immunology, University of MinnesotaDepartment of Microbiology and Immunology, Center for Immunology, University of MinnesotaDepartment of Laboratory Medicine and Pathology, Center for Immunology, University of MinnesotaDepartment of Pediatrics, Center for Immunology, University of MinnesotaDepartment of Neurosurgery, University of MinnesotaDepartment of Obstetrics, Gynecology and Women’s Health, University of MinnesotaDepartment of Microbiology and Immunology, Center for Immunology, University of MinnesotaDepartment of Microbiology and Immunology, Center for Immunology, University of MinnesotaThe immunosuppressive tumor environment and the lack of functional anti-tumor immunity are major limiting factors in immunotherapy. Here the authors show that human and mouse tumors are infiltrated by virus-specific memory T cells, which can be harnessed by viral peptides to induce local and systemic anti-tumor immunity and synergize with checkpoint blockade.https://doi.org/10.1038/s41467-019-08534-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Pamela C. Rosato Sathi Wijeyesinghe J. Michael Stolley Christine E. Nelson Rachel L. Davis Luke S. Manlove Christopher A. Pennell Bruce R. Blazar Clark C. Chen Melissa A. Geller Vaiva Vezys David Masopust
spellingShingle	Pamela C. Rosato Sathi Wijeyesinghe J. Michael Stolley Christine E. Nelson Rachel L. Davis Luke S. Manlove Christopher A. Pennell Bruce R. Blazar Clark C. Chen Melissa A. Geller Vaiva Vezys David Masopust Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy Nature Communications
author_facet	Pamela C. Rosato Sathi Wijeyesinghe J. Michael Stolley Christine E. Nelson Rachel L. Davis Luke S. Manlove Christopher A. Pennell Bruce R. Blazar Clark C. Chen Melissa A. Geller Vaiva Vezys David Masopust
author_sort	Pamela C. Rosato
title	Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy
title_short	Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy
title_full	Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy
title_fullStr	Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy
title_full_unstemmed	Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy
title_sort	virus-specific memory t cells populate tumors and can be repurposed for tumor immunotherapy
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-02-01
description	The immunosuppressive tumor environment and the lack of functional anti-tumor immunity are major limiting factors in immunotherapy. Here the authors show that human and mouse tumors are infiltrated by virus-specific memory T cells, which can be harnessed by viral peptides to induce local and systemic anti-tumor immunity and synergize with checkpoint blockade.
url	https://doi.org/10.1038/s41467-019-08534-1
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Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy

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