A Model for Protein Sequence Evolution Based on Selective Pressure for Protein Stability: Application to Hemoglobins

Negative selection against protein instability is a central influence on evolution of proteins. Protein stability is maintained over evolution despite changes in underlying sequences. An empirical all-site stability-based model of evolution was developed to focus on the selection of residues arising...

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Main Author: Lorraine Marsh
Format: Article
Language:English
Published: SAGE Publishing 2009-08-01
Series:Evolutionary Bioinformatics
Online Access:http://la-press.com/a-model-for-protein-sequence-evolution-based-on-selective-pressure-for-a1608
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spelling doaj-5eea00be98444a91921c00d7d53dbe5c2020-11-25T04:00:20ZengSAGE PublishingEvolutionary Bioinformatics1176-93432009-08-0120095107118A Model for Protein Sequence Evolution Based on Selective Pressure for Protein Stability: Application to HemoglobinsLorraine MarshNegative selection against protein instability is a central influence on evolution of proteins. Protein stability is maintained over evolution despite changes in underlying sequences. An empirical all-site stability-based model of evolution was developed to focus on the selection of residues arising from their contributions to protein stability. In this model, site rates could vary. A structure-based method was used to predict stationary frequencies of hemoglobin residues based on their propensity to promote protein stability at a site. Sites with destabilizing residues were shown to change more rapidly in hemoglobins than sites with stabilizing residues. For diverse proteins the results were consistent with stability-based selection. Maximum likelihood studies with hemoglobins supported the stability-based model over simple Poisson-based methods. These observations are consistent with suggestions that purifying selection to maintain protein structural stability plays a dominant role in protein evolution. http://la-press.com/a-model-for-protein-sequence-evolution-based-on-selective-pressure-for-a1608
collection DOAJ
language English
format Article
sources DOAJ
author Lorraine Marsh
spellingShingle Lorraine Marsh
A Model for Protein Sequence Evolution Based on Selective Pressure for Protein Stability: Application to Hemoglobins
Evolutionary Bioinformatics
author_facet Lorraine Marsh
author_sort Lorraine Marsh
title A Model for Protein Sequence Evolution Based on Selective Pressure for Protein Stability: Application to Hemoglobins
title_short A Model for Protein Sequence Evolution Based on Selective Pressure for Protein Stability: Application to Hemoglobins
title_full A Model for Protein Sequence Evolution Based on Selective Pressure for Protein Stability: Application to Hemoglobins
title_fullStr A Model for Protein Sequence Evolution Based on Selective Pressure for Protein Stability: Application to Hemoglobins
title_full_unstemmed A Model for Protein Sequence Evolution Based on Selective Pressure for Protein Stability: Application to Hemoglobins
title_sort model for protein sequence evolution based on selective pressure for protein stability: application to hemoglobins
publisher SAGE Publishing
series Evolutionary Bioinformatics
issn 1176-9343
publishDate 2009-08-01
description Negative selection against protein instability is a central influence on evolution of proteins. Protein stability is maintained over evolution despite changes in underlying sequences. An empirical all-site stability-based model of evolution was developed to focus on the selection of residues arising from their contributions to protein stability. In this model, site rates could vary. A structure-based method was used to predict stationary frequencies of hemoglobin residues based on their propensity to promote protein stability at a site. Sites with destabilizing residues were shown to change more rapidly in hemoglobins than sites with stabilizing residues. For diverse proteins the results were consistent with stability-based selection. Maximum likelihood studies with hemoglobins supported the stability-based model over simple Poisson-based methods. These observations are consistent with suggestions that purifying selection to maintain protein structural stability plays a dominant role in protein evolution.
url http://la-press.com/a-model-for-protein-sequence-evolution-based-on-selective-pressure-for-a1608
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