Radioprotective influence on mice DNA of biopolymer complexes from tinder Fomes Fomentarius under ionizing radiation in small doses

• Main Authors: O. F. Seniuk, V. O. Kovalev, L. A. Palamar, M. I. Krul, L. F. Gorovoj
• Format: Article
• Language: English
• Published: Institute for Nuclear Research, National Academy of Sciences of Ukraine 2014-03-01
• Series: Âderna Fìzika ta Energetika
• Subjects: ionizing radiation; acute and chronic effects; DNA; fungal biopolymers
• Online Access: http://jnpae.kinr.kiev.ua/15.1/Articles_PDF/jnpae-2014-15-0073-Seniuk.pdf

The effects of similar doses of the values of common external irradiation (0,19 Gy/4hours and 0,24 Gy/6 months) at single-strand DNA breaks and the level of the hydrogen bonds in this molecule in different cell types (lymphocytes, hepatocytes and splenocytes) linear mice CC57W/mv are discussed. Mice were exposed to γ-fields produced by “hot” particles of emergency 4-th Chernobyl Unit containing the same radionuclides in the proportions. The possibility of leveling the radiation effects using complex biopolymers from Fomes fomentarius was shown. The ability of melanin-glucan complex to directly counteract the fragmentation of DNA in a model system with lambda phage this macromolecule oxidation products of benzidine and neutralize mutagenic effect in Salmonella typhimurium strains in the classical Ames test was studied.