Potential role of transforming growth factor β1 and interleukin-6 in elderly type 2 diabetes mellitus patients

• Main Authors: M.S. Roopakala, Mahesh Eshwarappa, C.R. Wilma Delphine Silvia, Pushpa Krishna, Vasanth Kumar, S. Chandrashekara, K.M. Prasanna Kumar
• Format: Article
• Language: English
• Published: Al Ameen Medical College 2014-04-01
• Series: Al Ameen Journal of Medical Sciences
• Subjects: Cytokines; TGF-β 1; IL -6; Type 2 DM; Nephropathy
• Online Access: http://ajms.alameenmedical.org/ArticlePDFs/AJMS%20V7.N2.2014%20p%20160-163.pdf
• ISSN: 0974-1143; 0974-1143

Background: Studies suggest that various cytokines like TGF-β1 and IL-6 mediate development and progression of diabetic nephropathy. Aim: To determine the role of cytokines by evaluating the plasma levels of TGF-β1 & IL-6 in Type 2 DM elderly patients with different degree of renal function insufficiency. Settings and Design: Cross sectional. Material and Methods: This study comprised of seventy three type2 DM patients between 50-60 years and 44 age & sex matched controls were enrolled in the study were sampled for Serum (Creatinine and HbA1C) and Urine (Albumin and Creatinine). Type 2 DM patients were stratified into normoalbuminura, microalbuminuria and macroalbuminuria. Plasma TGF-β1 and IL-6 were analyzed by ELISA method. Serum TGF-β1 and IL-6 levels were increased in Type 2 DM patients compared with controls. Statistical analysis: Tukey Post-hoc test, Analysis of variance and Mann Whitney U test were used for statistical analysis of the results. Results and Conclusion: The mean TGF-β1 and IL-6 were significantly different among the groups with increased level in subjects with macroalbuminuria. This study confirms the role of cytokines in development of diabetic nephropathy.