The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction

The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction

The beating heart adapts cardiac output to changes in mechanical load via incompletely understood mechanotransduction mechanisms. Here the authors show that the mechanosensitive Piezo1 channel serves as a mechanotransducer for directly converting mechanical stretch of cardiomyocytes into Ca2+ and RO...

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Main Authors: Fan Jiang, Kunlun Yin, Kun Wu, Mingmin Zhang, Shiqiang Wang, Heping Cheng, Zhou Zhou, Bailong Xiao
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21178-4
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spelling doaj-5ede68f3d2b2430db4de9c5749801c0f2021-02-14T12:11:21ZengNature Publishing GroupNature Communications2041-17232021-02-0112111410.1038/s41467-021-21178-4The mechanosensitive Piezo1 channel mediates heart mechano-chemo transductionFan Jiang0Kunlun Yin1Kun Wu2Mingmin Zhang3Shiqiang Wang4Heping Cheng5Zhou Zhou6Bailong Xiao7State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, IDG/McGovern Institute for Brain Research, School of Pharmaceutical Sciences, Tsinghua UniversityState Key Laboratory of Cardiovascular Disease, Beijing Key Laboratory for Molecular Diagnostics of Cardiovascular Diseases, Center of Laboratory Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeState Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, IDG/McGovern Institute for Brain Research, School of Pharmaceutical Sciences, Tsinghua UniversityState Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, IDG/McGovern Institute for Brain Research, School of Pharmaceutical Sciences, Tsinghua UniversityState Key Laboratory of Membrane Biology, College of Life Sciences and Institute of Molecular Medicine, Peking UniversityState Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Peking UniversityState Key Laboratory of Cardiovascular Disease, Beijing Key Laboratory for Molecular Diagnostics of Cardiovascular Diseases, Center of Laboratory Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeState Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, IDG/McGovern Institute for Brain Research, School of Pharmaceutical Sciences, Tsinghua UniversityThe beating heart adapts cardiac output to changes in mechanical load via incompletely understood mechanotransduction mechanisms. Here the authors show that the mechanosensitive Piezo1 channel serves as a mechanotransducer for directly converting mechanical stretch of cardiomyocytes into Ca2+ and ROS signaling and consequently maintaining normal heart function.https://doi.org/10.1038/s41467-021-21178-4
collection DOAJ
language English
format Article
sources DOAJ
author Fan Jiang
Kunlun Yin
Kun Wu
Mingmin Zhang
Shiqiang Wang
Heping Cheng
Zhou Zhou
Bailong Xiao
spellingShingle Fan Jiang
Kunlun Yin
Kun Wu
Mingmin Zhang
Shiqiang Wang
Heping Cheng
Zhou Zhou
Bailong Xiao
The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction
Nature Communications
author_facet Fan Jiang
Kunlun Yin
Kun Wu
Mingmin Zhang
Shiqiang Wang
Heping Cheng
Zhou Zhou
Bailong Xiao
author_sort Fan Jiang
title The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction
title_short The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction
title_full The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction
title_fullStr The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction
title_full_unstemmed The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction
title_sort mechanosensitive piezo1 channel mediates heart mechano-chemo transduction
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-02-01
description The beating heart adapts cardiac output to changes in mechanical load via incompletely understood mechanotransduction mechanisms. Here the authors show that the mechanosensitive Piezo1 channel serves as a mechanotransducer for directly converting mechanical stretch of cardiomyocytes into Ca2+ and ROS signaling and consequently maintaining normal heart function.
url https://doi.org/10.1038/s41467-021-21178-4
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