Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex

Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex

Tuberous sclerosis complex (TSC) is a neurodevelopmental disease caused by TSC1 or TSC2 mutations and subsequent activation of the mTORC1 kinase. Upon mTORC1 activation, anabolic metabolism, which requires mitochondria, is induced, yet at the same time the principal pathway for mitochondrial turnove...

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Bibliographic Details
Main Authors: Darius Ebrahimi-Fakhari, Afshin Saffari, Lara Wahlster, Alessia Di Nardo, Daria Turner, Tommy L. Lewis Jr., Christopher Conrad, Jonathan M. Rothberg, Jonathan O. Lipton, Stefan Kölker, Georg F. Hoffmann, Min-Joon Han, Franck Polleux, Mustafa Sahin
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
mTOR
mTORC1
autophagy
mitochondria
autism
axonal transport
synapse
lysosome
rapamycin
carbamazepine
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716312931

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http://www.sciencedirect.com/science/article/pii/S2211124716312931

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