A multi-center, randomized, clinical study to compare the effect and safety of autologous cultured osteoblast(Ossron™) injection to treat fractures

• Main Authors: Jeon Taek-Soo, Sung Yerl-Bo, Won Yoo-Dong, Im Soo-Ah, Han Suk-Ku, Yoo Moon-Jib, Kim Sang-Bum, Yang Kyu-Hyun, Shin Yong-Woon, Kim Seok-Jung, Chang Cheong-Ho, Jang Jae-Deog, Lee Sae-Bom, Kim Hyun-Cho, Lee Soo-Young
• Format: Article
• Language: English
• Published: BMC 2009-02-01
• Series: BMC Musculoskeletal Disorders
• Online Access: http://www.biomedcentral.com/1471-2474/10/20

<p>Abstract</p> <p>Background</p> <p>We performed a multicenter, open, randomized, clinical study of autologous cultured osteoblast injection for long-bone fracture, to evaluate the fracture healing acceleration effect and the safety of autologous cultured osteoblasts.</p> <p>Methods</p> <p>Sixty-four patients with long-bone fractures were randomly divided into two groups, i.e. those who received autologous cultured osteoblast injection and those who received no treatment. The sum of the difference in the callus formation scores after four and eight weeks, was used as the first efficacy variable.</p> <p>Results</p> <p>The autologous cultured osteoblast injection group showed fracture healing acceleration of statistical significance, and there were no specific patient complications when using this treatment.</p> <p>Conclusion</p> <p>Autologous cultured osteoblast injection should therefore be considered as a successful treatment option for treating long-bone fracture.</p> <p>Trial registration</p> <p>Current Controlled Trials ISRCTN10637905</p>