IL-17C Mitigates Murine Acute Graft-vs.-Host Disease by Promoting Intestinal Barrier Functions and Treg Differentiation

IL-17C Mitigates Murine Acute Graft-vs.-Host Disease by Promoting Intestinal Barrier Functions and Treg Differentiation

Acute graft-vs.-host disease (aGVHD) is one of the major complications and results in high mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). IL-17C is involved in many inflammatory immune disorders. However, the role of IL-17C in aGVHD remains unknown. Here we demonstra...

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Bibliographic Details
Main Authors: Huanle Gong, Shoubao Ma, Shuangzhu Liu, Yonghao Liu, Ziqi Jin, Ying Zhu, Yuan Song, Lei Lei, Bo Hu, Yu Mei, Hong Liu, Yuejun Liu, Yan Wu, Chen Dong, Yang Xu, Depei Wu, Haiyan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
IL-17C
Acute graft-vs.-host disease
Treg cells
intestinal barrier functions
inflammation
transplantation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02724/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02724/full

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