Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation

Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation

Survival of Trypanosoma brucei depends upon switches in its protective Variant Surface Glycoprotein (VSG) coat by antigenic variation. VSG switching occurs by frequent homologous recombination, which is thought to require locus-specific initiation. Here, we show that a RecQ helicase, RECQ2, acts to...

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Bibliographic Details
Main Authors: Rebecca Devlin, Catarina A Marques, Daniel Paape, Marko Prorocic, Andrea C Zurita-Leal, Samantha J Campbell, Craig Lapsley, Nicholas Dickens, Richard McCulloch
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-05-01
Series:eLife
Subjects:
Trypanosoma
antigenic variation
Variant Surface Glycoprotein
DNA repair
DNA replication
DNA break
Online Access:https://elifesciences.org/articles/12765

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