ST2 deficiency does not impair type 2 immune responses during chronic filarial infection but leads to an increased microfilaremia due to an impaired splenic microfilarial clearance.

ST2 deficiency does not impair type 2 immune responses during chronic filarial infection but leads to an increased microfilaremia due to an impaired splenic microfilarial clearance.

Interactions of the Th2 cytokine IL-33 with its receptor ST2 lead to amplified Type 2 immune responses. As Type 2 immune responses are known to mediate protection against helminth infections we hypothesized that the lack of ST2 would lead to an increased susceptibility to filarial infections.ST2 def...

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Bibliographic Details
Main Authors: Jesuthas Ajendra, Sabine Specht, Anna-Lena Neumann, Fabian Gondorf, David Schmidt, Katrin Gentil, Wolfgang H Hoffmann, Mark J Taylor, Achim Hoerauf, Marc P Hübner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3963995?pdf=render

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