Humanized anti-DEspR IgG4S228P antibody increases overall survival in a pancreatic cancer stem cell-xenograft peritoneal carcinomatosis rat nu/nu model

Humanized anti-DEspR IgG4S228P antibody increases overall survival in a pancreatic cancer stem cell-xenograft peritoneal carcinomatosis rat nu/nu model

Abstract Background Pancreatic peritoneal carcinomatosis (PPC), with the worst median overall-survival (mOS), epitomizes the incurability of metastatic cancer. Cancer stem cells (CSCs) underpin this incurability. However, inhibitors of CSC-stemness fail to increase mOS in cancer patients despite pre...

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Bibliographic Details
Main Authors: Christopher M. Gromisch, Glaiza L. A. Tan, Khristine Amber Pasion, Ann-Marie Moran, Matthew S. Gromisch, Mark W. Grinstaff, Francis J. Carr, Victoria L. M. Herrera, Nelson Ruiz-Opazo
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Cancer
Subjects:
Dual endothelin-1/signal peptide receptor
DEspR
Cancer stem cells
Pancreatic cancer
Peritoneal carcinomatosis
Nude rat xenograft tumor model
Online Access:https://doi.org/10.1186/s12885-021-08107-w

Internet

https://doi.org/10.1186/s12885-021-08107-w

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