Changes in oncogenic protein levels in peri-implant oral malignancy: a case report

Abstract Background Oral squamous cell carcinoma (OSCC) constitutes a group of tumors that exhibit heterogeneous biology, histopathology, and clinical behaviors. Case presentation A 73-year-old male had a whitish leukoplakia-like lesion around inflamed peri-implant area (#42, #43, and #44), and this...

Full description

Bibliographic Details
Main Authors: Mi Hyun Seo, Hoon Myoung, Jong Ho Lee, Soung Min Kim, Suk Keun Lee
Format: Article
Language:English
Published: SpringerOpen 2019-11-01
Series:Maxillofacial Plastic and Reconstructive Surgery
Subjects:
Online Access:http://link.springer.com/article/10.1186/s40902-019-0235-z
id doaj-5ea12c58a81847c0ab643980e3f04ff1
record_format Article
spelling doaj-5ea12c58a81847c0ab643980e3f04ff12020-11-25T04:07:21ZengSpringerOpenMaxillofacial Plastic and Reconstructive Surgery2288-85862019-11-014111910.1186/s40902-019-0235-zChanges in oncogenic protein levels in peri-implant oral malignancy: a case reportMi Hyun Seo0Hoon Myoung1Jong Ho Lee2Soung Min Kim3Suk Keun Lee4Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National UniversityDepartment of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National UniversityDepartment of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National UniversityDepartment of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National UniversityDepartment of Oral Pathology, College of Dentistry, Gangneung-Wonju National UniversityAbstract Background Oral squamous cell carcinoma (OSCC) constitutes a group of tumors that exhibit heterogeneous biology, histopathology, and clinical behaviors. Case presentation A 73-year-old male had a whitish leukoplakia-like lesion around inflamed peri-implant area (#42, #43, and #44), and this lesion had transformed to OSCC within 3 years. He underwent mass resection, selective neck dissection, and reconstructive surgery. To detect any carcinogenesis progression, we examined the removed tumor tissue as well as the patient’s preoperative and postoperative sera to identify causative oncogenic proteins using immunoprecipitation high-performance liquid chromatography (IP-HPLC). Conclusions The protein expression levels of p53, E-cadherin, β-catenin, MMP-10, HER2, NRAS, Met, HER2, and ERb were significantly lower in the serum collected on postoperative day 10 than in the preoperative serum, and if these proteins are consistently not elevated in the serum 3 months after surgery compared with the preoperative serum, these proteins can be potential oncogenic proteins. However, we also found that the serum extracted 3 months after the operation had elevated levels of oncogenic proteins compared with that of the preoperative and 10-day postoperative serum indicating the possibility of tumor recurrence. At postoperative follow-up period, ipsilateral neck metastasis and second primary lesion were found and additional surgery was performed to the patient. IP-HPLC using the patient’s serum shows the possibility of oncogenic protein detection. However, follow-up IP-HPLC data is needed to find out patient-specific prognostic factors.http://link.springer.com/article/10.1186/s40902-019-0235-zOral squamous cell carcinoma (OSCC)Immunoprecipitation high-performance liquid chromatography (IP-HPLC)Oncogenic proteinPeri-implant oral malignancy (PIOM)
collection DOAJ
language English
format Article
sources DOAJ
author Mi Hyun Seo
Hoon Myoung
Jong Ho Lee
Soung Min Kim
Suk Keun Lee
spellingShingle Mi Hyun Seo
Hoon Myoung
Jong Ho Lee
Soung Min Kim
Suk Keun Lee
Changes in oncogenic protein levels in peri-implant oral malignancy: a case report
Maxillofacial Plastic and Reconstructive Surgery
Oral squamous cell carcinoma (OSCC)
Immunoprecipitation high-performance liquid chromatography (IP-HPLC)
Oncogenic protein
Peri-implant oral malignancy (PIOM)
author_facet Mi Hyun Seo
Hoon Myoung
Jong Ho Lee
Soung Min Kim
Suk Keun Lee
author_sort Mi Hyun Seo
title Changes in oncogenic protein levels in peri-implant oral malignancy: a case report
title_short Changes in oncogenic protein levels in peri-implant oral malignancy: a case report
title_full Changes in oncogenic protein levels in peri-implant oral malignancy: a case report
title_fullStr Changes in oncogenic protein levels in peri-implant oral malignancy: a case report
title_full_unstemmed Changes in oncogenic protein levels in peri-implant oral malignancy: a case report
title_sort changes in oncogenic protein levels in peri-implant oral malignancy: a case report
publisher SpringerOpen
series Maxillofacial Plastic and Reconstructive Surgery
issn 2288-8586
publishDate 2019-11-01
description Abstract Background Oral squamous cell carcinoma (OSCC) constitutes a group of tumors that exhibit heterogeneous biology, histopathology, and clinical behaviors. Case presentation A 73-year-old male had a whitish leukoplakia-like lesion around inflamed peri-implant area (#42, #43, and #44), and this lesion had transformed to OSCC within 3 years. He underwent mass resection, selective neck dissection, and reconstructive surgery. To detect any carcinogenesis progression, we examined the removed tumor tissue as well as the patient’s preoperative and postoperative sera to identify causative oncogenic proteins using immunoprecipitation high-performance liquid chromatography (IP-HPLC). Conclusions The protein expression levels of p53, E-cadherin, β-catenin, MMP-10, HER2, NRAS, Met, HER2, and ERb were significantly lower in the serum collected on postoperative day 10 than in the preoperative serum, and if these proteins are consistently not elevated in the serum 3 months after surgery compared with the preoperative serum, these proteins can be potential oncogenic proteins. However, we also found that the serum extracted 3 months after the operation had elevated levels of oncogenic proteins compared with that of the preoperative and 10-day postoperative serum indicating the possibility of tumor recurrence. At postoperative follow-up period, ipsilateral neck metastasis and second primary lesion were found and additional surgery was performed to the patient. IP-HPLC using the patient’s serum shows the possibility of oncogenic protein detection. However, follow-up IP-HPLC data is needed to find out patient-specific prognostic factors.
topic Oral squamous cell carcinoma (OSCC)
Immunoprecipitation high-performance liquid chromatography (IP-HPLC)
Oncogenic protein
Peri-implant oral malignancy (PIOM)
url http://link.springer.com/article/10.1186/s40902-019-0235-z
work_keys_str_mv AT mihyunseo changesinoncogenicproteinlevelsinperiimplantoralmalignancyacasereport
AT hoonmyoung changesinoncogenicproteinlevelsinperiimplantoralmalignancyacasereport
AT jongholee changesinoncogenicproteinlevelsinperiimplantoralmalignancyacasereport
AT soungminkim changesinoncogenicproteinlevelsinperiimplantoralmalignancyacasereport
AT sukkeunlee changesinoncogenicproteinlevelsinperiimplantoralmalignancyacasereport
_version_ 1724429167421816832