Characterization and Potential Antidiabetic Activity of Proanthocyanidins from the Barks of Acacia mangium and Larix gmelinii

Characterization and Potential Antidiabetic Activity of Proanthocyanidins from the Barks of Acacia mangium and Larix gmelinii

Proanthocyanidins in ethanol extracts from the barks of Acacia mangium and Larix gmelinii were analyzed by gel permeation chromatography, MALDI-TOF/TOF MS, and HPLC/MS. The inhibitory effects of proanthocyanidins and acid-catalyzed hydrolysis of proanthocyanidins against carbolytic enzymes were also...

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Main Authors: X. Chen, J. Xiong, Q. He, F. Wang
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2019/4793047
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spelling doaj-5e94ded8791b4d899358cb16ba0872232020-11-25T01:38:09ZengHindawi LimitedJournal of Chemistry2090-90632090-90712019-01-01201910.1155/2019/47930474793047Characterization and Potential Antidiabetic Activity of Proanthocyanidins from the Barks of Acacia mangium and Larix gmeliniiX. Chen0J. Xiong1Q. He2F. Wang3College of Chemical Engineering, Nanjing Forestry University, Jiangsu Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Nanjing 210037, ChinaPlants for Human Health Institute, Food Bioprocessing and Nutrition Sciences Department, North Carolina State University, North Carolina Research Campus, Kannapolis, NC 28081, USACollege of Chemical Engineering, Nanjing Forestry University, Jiangsu Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Nanjing 210037, ChinaCollege of Chemical Engineering, Nanjing Forestry University, Jiangsu Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Nanjing 210037, ChinaProanthocyanidins in ethanol extracts from the barks of Acacia mangium and Larix gmelinii were analyzed by gel permeation chromatography, MALDI-TOF/TOF MS, and HPLC/MS. The inhibitory effects of proanthocyanidins and acid-catalyzed hydrolysis of proanthocyanidins against carbolytic enzymes were also tested. A significant relationship between carbolytic enzymes inhibition and degree of polymerization was established, showing that the degree of polymerization is a major contributor to the biological activity of the proanthocyanidins from both types of woody plant bark. The results indicate that proanthocyanidins from the barks of A. mangium and L. gmelinii have potential antidiabetic properties.http://dx.doi.org/10.1155/2019/4793047
collection DOAJ
language English
format Article
sources DOAJ
author X. Chen
J. Xiong
Q. He
F. Wang
spellingShingle X. Chen
J. Xiong
Q. He
F. Wang
Characterization and Potential Antidiabetic Activity of Proanthocyanidins from the Barks of Acacia mangium and Larix gmelinii
Journal of Chemistry
author_facet X. Chen
J. Xiong
Q. He
F. Wang
author_sort X. Chen
title Characterization and Potential Antidiabetic Activity of Proanthocyanidins from the Barks of Acacia mangium and Larix gmelinii
title_short Characterization and Potential Antidiabetic Activity of Proanthocyanidins from the Barks of Acacia mangium and Larix gmelinii
title_full Characterization and Potential Antidiabetic Activity of Proanthocyanidins from the Barks of Acacia mangium and Larix gmelinii
title_fullStr Characterization and Potential Antidiabetic Activity of Proanthocyanidins from the Barks of Acacia mangium and Larix gmelinii
title_full_unstemmed Characterization and Potential Antidiabetic Activity of Proanthocyanidins from the Barks of Acacia mangium and Larix gmelinii
title_sort characterization and potential antidiabetic activity of proanthocyanidins from the barks of acacia mangium and larix gmelinii
publisher Hindawi Limited
series Journal of Chemistry
issn 2090-9063
2090-9071
publishDate 2019-01-01
description Proanthocyanidins in ethanol extracts from the barks of Acacia mangium and Larix gmelinii were analyzed by gel permeation chromatography, MALDI-TOF/TOF MS, and HPLC/MS. The inhibitory effects of proanthocyanidins and acid-catalyzed hydrolysis of proanthocyanidins against carbolytic enzymes were also tested. A significant relationship between carbolytic enzymes inhibition and degree of polymerization was established, showing that the degree of polymerization is a major contributor to the biological activity of the proanthocyanidins from both types of woody plant bark. The results indicate that proanthocyanidins from the barks of A. mangium and L. gmelinii have potential antidiabetic properties.
url http://dx.doi.org/10.1155/2019/4793047
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AT qhe characterizationandpotentialantidiabeticactivityofproanthocyanidinsfromthebarksofacaciamangiumandlarixgmelinii
AT fwang characterizationandpotentialantidiabeticactivityofproanthocyanidinsfromthebarksofacaciamangiumandlarixgmelinii
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