Harnessing A3G for efficient and selective C-to-T conversion at C-rich sequences

Harnessing A3G for efficient and selective C-to-T conversion at C-rich sequences

Abstract Background Site-specific C>T DNA base editing has been achieved by recruiting cytidine deaminases to the target C using catalytically impaired Cas proteins; the target C is typically located within 5-nt editing window specified by the guide RNAs. The prototypical cytidine base editor BE3...

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Bibliographic Details
Main Authors: Wenxia Yu, Jianan Li, Shisheng Huang, Xiangyang Li, Ping Li, Guanglei Li, Aibin Liang, Tian Chi, Xingxu Huang
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Biology
Subjects:
Base editing
Apobec 3G
Motif
C-rich
Online Access:https://doi.org/10.1186/s12915-020-00879-0

Internet

https://doi.org/10.1186/s12915-020-00879-0

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