Old Receptor, New Tricks—The Ever-Expanding Universe of Aryl Hydrocarbon Receptor Functions. Report from the 4th AHR Meeting, 29–31 August 2018 in Paris, France
In a time where “translational„ science has become a mantra in the biomedical field, it is reassuring when years of research into a biological phenomenon suddenly points towards novel prevention or therapeutic approaches to disease, thereby demonstrating once again that basic sci...
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/19/11/3603 |
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doaj-5e8ec74bb2d4433482dfe997a21088792020-11-24T22:37:33ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-11-011911360310.3390/ijms19113603ijms19113603Old Receptor, New Tricks—The Ever-Expanding Universe of Aryl Hydrocarbon Receptor Functions. Report from the 4th AHR Meeting, 29–31 August 2018 in Paris, FranceCharlotte Esser0B. Paige Lawrence1David H. Sherr2Gary H. Perdew3Alvaro Puga4Robert Barouki5Xavier Coumoul6IUF-Leibniz Research Institute for Environmental Medicine, Auf´m Hennekamp 50, 40225 Düsseldorf, GermanyEnvironmental Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USADepartment of Environmental Health, Boston University School of Public Health, 72 East Concord Street, Boston, MA 02118, USACenter for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USADepartment of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USAToxicologie Pharmacologie et Signalisation Cellulaire, INSERM UMR-S1124, 45 rue des Saints-Pères, 75006 Paris, FranceToxicologie Pharmacologie et Signalisation Cellulaire, INSERM UMR-S1124, 45 rue des Saints-Pères, 75006 Paris, FranceIn a time where “translational„ science has become a mantra in the biomedical field, it is reassuring when years of research into a biological phenomenon suddenly points towards novel prevention or therapeutic approaches to disease, thereby demonstrating once again that basic science and translational science are intimately linked. The studies on the aryl hydrocarbon receptor (AHR) discussed here provide a perfect example of how years of basic toxicological research on a molecule, whose normal physiological function remained a mystery for so long, has now yielded a treasure trove of actionable information on the development of targeted therapeutics. Examples are autoimmunity, metabolic imbalance, inflammatory skin and gastro-intestinal diseases, cancer, development and perhaps ageing. Indeed, the AHR field no longer asks, “What does this receptor do in the absence of xenobiotics?„ It now asks, “What doesn’t this receptor do?„.https://www.mdpi.com/1422-0067/19/11/3603transcription factortranslational scienceenvironmental healthbarrier organsstem cellsnervous systemobesitycancerimmunitydevelopmentdiet |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Charlotte Esser B. Paige Lawrence David H. Sherr Gary H. Perdew Alvaro Puga Robert Barouki Xavier Coumoul |
| spellingShingle |
Charlotte Esser B. Paige Lawrence David H. Sherr Gary H. Perdew Alvaro Puga Robert Barouki Xavier Coumoul Old Receptor, New Tricks—The Ever-Expanding Universe of Aryl Hydrocarbon Receptor Functions. Report from the 4th AHR Meeting, 29–31 August 2018 in Paris, France International Journal of Molecular Sciences transcription factor translational science environmental health barrier organs stem cells nervous system obesity cancer immunity development diet |
| author_facet |
Charlotte Esser B. Paige Lawrence David H. Sherr Gary H. Perdew Alvaro Puga Robert Barouki Xavier Coumoul |
| author_sort |
Charlotte Esser |
| title |
Old Receptor, New Tricks—The Ever-Expanding Universe of Aryl Hydrocarbon Receptor Functions. Report from the 4th AHR Meeting, 29–31 August 2018 in Paris, France |
| title_short |
Old Receptor, New Tricks—The Ever-Expanding Universe of Aryl Hydrocarbon Receptor Functions. Report from the 4th AHR Meeting, 29–31 August 2018 in Paris, France |
| title_full |
Old Receptor, New Tricks—The Ever-Expanding Universe of Aryl Hydrocarbon Receptor Functions. Report from the 4th AHR Meeting, 29–31 August 2018 in Paris, France |
| title_fullStr |
Old Receptor, New Tricks—The Ever-Expanding Universe of Aryl Hydrocarbon Receptor Functions. Report from the 4th AHR Meeting, 29–31 August 2018 in Paris, France |
| title_full_unstemmed |
Old Receptor, New Tricks—The Ever-Expanding Universe of Aryl Hydrocarbon Receptor Functions. Report from the 4th AHR Meeting, 29–31 August 2018 in Paris, France |
| title_sort |
old receptor, new tricks—the ever-expanding universe of aryl hydrocarbon receptor functions. report from the 4th ahr meeting, 29–31 august 2018 in paris, france |
| publisher |
MDPI AG |
| series |
International Journal of Molecular Sciences |
| issn |
1422-0067 |
| publishDate |
2018-11-01 |
| description |
In a time where “translational„ science has become a mantra in the biomedical field, it is reassuring when years of research into a biological phenomenon suddenly points towards novel prevention or therapeutic approaches to disease, thereby demonstrating once again that basic science and translational science are intimately linked. The studies on the aryl hydrocarbon receptor (AHR) discussed here provide a perfect example of how years of basic toxicological research on a molecule, whose normal physiological function remained a mystery for so long, has now yielded a treasure trove of actionable information on the development of targeted therapeutics. Examples are autoimmunity, metabolic imbalance, inflammatory skin and gastro-intestinal diseases, cancer, development and perhaps ageing. Indeed, the AHR field no longer asks, “What does this receptor do in the absence of xenobiotics?„ It now asks, “What doesn’t this receptor do?„. |
| topic |
transcription factor translational science environmental health barrier organs stem cells nervous system obesity cancer immunity development diet |
| url |
https://www.mdpi.com/1422-0067/19/11/3603 |
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