Spatiotemporal coupling and decoupling of gene transcription with DNA replication origins during embryogenesis in C. elegans

Spatiotemporal coupling and decoupling of gene transcription with DNA replication origins during embryogenesis in C. elegans

The primary task of developing embryos is genome replication, yet how DNA replication is integrated with the profound cellular changes that occur through development is largely unknown. Using an approach to map DNA replication at high resolution in C. elegans, we show that replication origins are ma...

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Bibliographic Details
Main Authors: Ehsan Pourkarimi, James M Bellush, Iestyn Whitehouse
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-12-01
Series:eLife
Subjects:
replication
epigenetic
gene organization
transcription
Online Access:https://elifesciences.org/articles/21728

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