Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity
Dysregulated mitochondrial metabolism during hepatic insulin resistance may contribute to pathophysiologies ranging from elevated glucose production to hepatocellular oxidative stress and inflammation. Given that obesity impairs insulin action but paradoxically activates mTORC1, we tested whether in...
Main Authors: | Blanka Kucejova, Joao Duarte, Santhosh Satapati, Xiaorong Fu, Olga Ilkayeva, Christopher B. Newgard, James Brugarolas, Shawn C. Burgess |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2016-07-01
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Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124716307252 |
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