Removal of the C6 Vaccinia Virus Interferon-β Inhibitor in the Hepatitis C Vaccine Candidate MVA-HCV Elicited in Mice High Immunogenicity in Spite of Reduced Host Gene Expression

Removal of the C6 Vaccinia Virus Interferon-β Inhibitor in the Hepatitis C Vaccine Candidate MVA-HCV Elicited in Mice High Immunogenicity in Spite of Reduced Host Gene Expression

Hepatitis C virus (HCV) represents a major global health problem for which a vaccine is not available. Modified vaccinia virus Ankara (MVA)-HCV is a unique HCV vaccine candidate based in the modified vaccinia virus Ankara (MVA) vector expressing the nearly full-length genome of HCV genotype 1a that...

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Bibliographic Details
Main Authors: María Q. Marín, Patricia Pérez, Carmen E. Gómez, Carlos Óscar S. Sorzano, Mariano Esteban, Juan García-Arriaza
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Viruses
Subjects:
HCV
poxvirus
MVA
vaccine
C6L
interferon
host gene expression
mice
cellular responses
humoral responses
Online Access:http://www.mdpi.com/1999-4915/10/8/414

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http://www.mdpi.com/1999-4915/10/8/414

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